Is Silly Putty Toxic. An independent toxicologist examined all crayola and silly putty products and determined that they contain no known toxic chemicals in sufficient amounts to be detrimental to the human body, even if eaten or breathed. It is not poisonous to pets if swallowed, but may present other problems.

Silly putty is a nontoxic substance and does not irritate the skin. When it is found in inorganic form it is highly toxic; It can also be used to facilitate grasp patterns with pediatric clients.