Distemper Vaccine Side Effects. Within hours of administration vaccination can provide meaningful protection against severe disease and death, and complete protection can occur within days. “vaccine reactions are rare, very rare,” dr.

The majority of dogs show no side effects from vaccination, but possible side effects of the distemper shot in dogs could range from soreness to mild fever. Recommended for the vaccination of healthy dogs as an aid in the prevention of disease caused by canine distemper virus, canine adenovirus type 1 (hepatitis), canine adenovirus type 2 (respiratory disease), canine parainfluenza virus, and canine parvovirus and against leptospiral disease due to l. For a few days after the inoculations, your dog may seem tired and listless.